Role of the Laboratory in the Diagnosis of Plasma Cell Leukemia, about Anobservation
نویسندگان
چکیده
The plasma cell leukemia (PCL) is an extremely uncommon malignant blood disorder with a pejorative prognosis. It is defined by the presence of at least 20% of plasma cells in the peripheral blood or an absolute number of circulating plasma cells greater than 2 G /L. It appears under two variants: secondary PCL that complicates known multiple myeloma and primitive PCL that is immediately leukemic. We report the case of a 56 years old male patient who presented 2 months before his hospitalization diffuse bone pains with asthenia. The CBC revealed an anemia and a leukocytosis. The blood smear objectified 3 G/L circulating plasma cells. The bone marrow exam noted a rich cellularity and a marrow invaded up to 60% by dystrophic plasma cells. The clinical presentation of the plasma cell leukemia, its cytological smear characteristics, immunophenotypical, pathophysiological, therapeutic approach and outcome will be reminded in this
منابع مشابه
Evaluation of FOXP1 gene expression in pediatric B-cell precursor acute lymphoblastic leukemia patients at remission induction therapy
Background: Transcription factors (TFs) play a key role in the development, therapy, and relapse of B-cell malignancies, such as B-cell precursor acute lymphoblastic leukemia (BCP-ALL). Given the essential function of Forkhead box protein P1 (FOXP1) transcription factor in the early development of B-cells, this study was designed to evaluate FOXP1 gene expression levels in pediatric BCP-ALL pat...
متن کاملHodgkin’s Lymphoma Occurring Secondary to Autologous Stem Cell Transplantation in Plasma Cell Leukemia; A Case Report
Survival of patients with multiple myeloma has improved substantially because of availability of new therapies including autotransplants, immunomodulating drugs and proteasome-inhibitors. Second primary cancers have emerged as an important determinant of morbidity and mortality among cancer survivors. Even though there is an increased risk of new cancers of the lymphoreticular and haematopoetic...
متن کاملPresenting Clinical and Laboratory Data of Childhood Acute Lymphoblastic Leukemia
Abstract Background Leukemia is the most prevalent childhood cancer and Acute Lymphoblastic Leukemia (ALL) constitutes 75% of all cases. The most frequent presenting symptoms are fever, weight loss and pallor. Early detection of clinical symptoms positively affects timely diagnosis. The objectives of the present study were to assess frequency of presenting symptoms, laboratory data, immune ph...
متن کاملHemophagocytic lymphohistiocytosis secondary to T-cell Acute Lymphoblastic Leukemia with membranous tonsillitis
Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening syndrome of excessive immune activation, which is characterized by fever, hepatosplenomegaly, cytopenias, hyperferritinemia, hypertriglyceridemia, and/or hypofibrinogenemia, and evidence of hemophagocytosis. Secondary HLH is often seen in adults and categorized based on autoimmune, infections-related, and malignancy-associated etiol...
متن کاملAn Unusual Presentation of Plasma Cell Leukemia with Undiagnosed Multiple Myeloma
A 54 year old man with history of cardiomyopathy and chronic fibrillation first presented with bloody diarrhea. Then during the assessment of his abnormal lab. data revealed cast nephropathy in renal biopsy, gamma peak in protein electrophoresis and fine lytic lesions in skull graphy. His bone marrow asp...
متن کامل